Publications

Stoy, H., Zwicky, K., Kuster, D., Lang, K.S., J. Krietsch, J. Schmid, K. A. Cimprich, H. Merrikh and M. Lopes. (2023) Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids. Nature Structural and Molecular Biology 30(3): 348-359. PMID: 36864174

 

Park, M., Jinshil, K., Feinstein, J., Lang, K.S., Ryu, S., Jeon, B. (2022) Development of fluoroquinolone resistance through antibiotic tolerance in Campylobacter jejuni. Microbiology Spectrum doi: 10.1128/spectrum.01667-22.  PMID: 36066254

 

Stoy, H., Lang, K.S., Merrikh, H., Lopes, M. (2022) Locus-specific analysis of replication and detection of DNA-RNA hybrids by immune electron microscopy. R-Loops in Methods in Molecular Biology.

 

Lang, K.S. and Merrikh, H. (2021) Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts. Cell Reports 34(9), 108797.

 

Ward T.L., Weber B.P., Mendoza K.M., Danzeisen J.L., Llop K., Lang K.S., Clayton J.B., Grace E., Brannon J., Radovic I., Beauclaire M., Heisel T.J., Knights D., Cardona C., Kogut M., Johnson C., Noll S.L., Arsenault R., Reed K.M., Johnson T.J. (2019) Antibiotics and Host-Tailored Probiotics Similarly Modulate Effects on the Developing Avian Microbiome, Mycobiome, and Host Gene Expression. mBio 10(5):e02171-19. doi: 10.1128/mBio.02171-19. PMID: 31615957; PMCID: PMC6794479.

 

Lang, K.S. and Merrikh, H. (2018) The clash of macromolecular titans: replication-transcription conflicts in bacteria. Annual Reviews Microbiology 72: 71-88.

 

Ma, D, Wang, Z., Merrikh, C.N., Lang, K.S., Lu, P., Li, X., Merrikh, H., Rao, Z., and Wu, W. (2018) Crystal structure of a membrane-bound O-acyltransferase. Nature 562(7726):286-290.

 

Lang, K.S.*, Hall, A.N.*, Merrikh, C.N., Ragheb, M., Tabakh, H., Pollack, A.J., Woodward, J.J., Dreifus, J.E., and Merrikh, H. (2017) Replication-transcription conflicts generate R-Loops that orchestrate bacterial stress survival and pathogenesis. Cell 170(4): 787-799.e18. *Equal contribution

 

Lang, K.S. and Johnson, T. J. (2016) Characterization of Acr2, an H-NS-like protein encoded on A/C2-type plasmids. Plasmid 87-88:17-27.

 

Johnson, T. J., Singer, R. S., Isaacson, R. E., Danzeisen, J. L., Lang, K.S., Klobuk, K., Rivet, B., Borewicz, K., Frye, J.G., Englen, M., Anderson, J.M. and Davies, P. R. (2015) In vivo transmission of an IncA/C plasmid in Escherichia coli depends on tetracycline concentration and acquisition of the plasmid results in a variable cost of fitness. Applied and Environmental Microbiology 81(10):3561-3570.

 

LaPara, T.M., Madson, M., Borchardt, S., Lang, K.S., and Johnson, T.J. (2015) Multiple discharges of treated municipal wastewater have a small effect on the quantities of numerous antibiotic resistance determinants in the upper Mississippi River. Environmental Science and Technology 49(19): 11509-15.

 

Lang, K.S. and Johnson, T.J. (2015) Transcriptome modulation due to A/C2 plasmid acquisition. Plasmid 80:83-89.

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Lang, K.S., Danzeisen, J.L., Xu, W., and Johnson, T.J. (2012) Transcriptome mapping of pAR060302, a blaCMY2 positive IncA/C plasmid. Applied and Environmental Microbiology 78: 3379-3386.

 

Lang, K.S., Anderson, J.M., Schwarz, S., Williamson, L., Handelsman, J., and Singer, R.S. (2010) Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics. Applied and Environmental Microbiology 76: 5321-5326.

 

Muñoz-Aguayo, J., Lang, K.S., LaPara, T.M., Gonzalez, G., and Singer, R.S. (2007) Evaluating the Effects of Chlortetracycline on the Proliferation of Antibiotic-Resistant Bacteria in a Simulated River Water Ecosystem. Applied and Environmental Microbiology 73:5421-5425.